بررسی اثر تک دوز پره گابالین خوراکی بر کنترل درد حاد پس از اعمال جراحی ارتوپدی
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Abstract:
Aim and Background : Postoperative acute pain management is necessary to prevent chronic pain. Pregabalin as a GABA analogue has been shown to have analgesic effects on postoperative pain. It has minimal side effects and is absorbed rapidly from the alimentary tract. The aim of this study was to evaluate the analgesic efficacy of single dose oral pregabalin on postoperative pain control after orthopedic surgeries performed under spinal anesthesia. Materials and Methods : Sixty patients, candidate for orthopedic surgery under spinal anesthesia, were randomly allocated into two groups. For the intervention group 150 mg oral Pregabalin and for the control group placebo were prescribed one hour before surgery. Visual Analogue Scale (VAS) for pain assessment and opioid consumption were evaluated in a 12 hour period after surgery. If pain score (VAS) was more than four, intravenous pethidine (0/5 mg/kg) was administered. Findings : No significant difference was found between the two groups, regarding demographic data. VAS in the post anesthesia care unit, 6, and 12 hours postoperatively in the pregabalin group was significantly less than the placebo group(p <0.05). Also pethidine consumption in the pregabalin group was significantly less than the placebo group (p=0.001 . ) Conclusions: Administration of a single dose pregabalin orally (150 mg), one hour before orthopedic surgery reduced post operative pain and opioid consumption.
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Background and aims: Although pregabalin shows efficacy against neuropathic pain, very limited evidence support postoperative analgesic efficacy. Our study objective to investigate analgesic efficacy of oral pregabalin in orthopedic surgery postoperative pain and opioid consumption. Materials and methods: A randomized, double-blind, placebo-controlled was performed in . Patients received i...
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Aim and Background: Optimal postoperative pain management is necessary after minor general surgery. Although pregabalin had been showed efficacy against neuropathic pain, very limited evidence support its postoperative analgesic efficacy. The aim of this study was to evaluate the analgesic efficacy of premedication with single oral dose of pregabalin for minor general s...
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زمینه: پرهگابالین درکنترل دردهای مزمن نورپاتیک موثر میباشد، ولی مطالعات اندکی در موردتاثیر آن در کنترل درد حاد بعد از عمل وجود دارد.هدف از این مطالعه بررسی تاثیر مقدار خوراکی این دارو درکنترل درد و میزان مصرف مخدر بعداز اعمال جراحی ارتوپدی میباشد.روش کار: در این مطالعه برای کنترل درد بعد از عمل جراحی ارتوپدی، پمپ کنترلوریدی درد pcaبرای تمام بیماران گذاشته شد. بیماران به دو گروه تقسیم شدند. ...
full textبررسی تاثیر تک دوز و دوز پایین پره گابالین در کنترل درد بعد از عمل جراحی هیسترکتومی ابدومینال
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اثر پیش درمانی با 300 میلی گرم پره گابالین خوراکی بر درد و مصرف مخدر پس از عمل در بیماران تحت اعمال جراحی الکتیو ارتوپدی
Aims and background: Nowadays, multimodal approach is used to control post-operative pain. Pregabalin has been shown to have analgesic effects on postoperative pain as a Gaba-Amino-Buteric (GABA) analogue. This prospective, randomized, double-blind, controlled study has evaluated the beneficial effect of Pregabalin pretreatment on postoperative pain and opioid consumption in patints under...
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Journal title
volume 5 issue 1
pages 62- 68
publication date 2014-04
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